The present study deals with optimization and formulation design by using factorial design software (Design Expert 8.0.7.1, Statease, USA). Response surface plots and main effect plots were utilised to study effect of variables on the response parameters. Aspirin (ASP) loaded Solid lipid nanoparticles (NLCs) were prepared using optimised process parameters and by microemulsion method using melted Glyceryl monosterate (GMS) as an oil phase and Poloxomer 407 water solution as an aqueous phase. Formulated ASP-NLCs were characterised for particle size, polydispersity index, zeta potential, drug entrapment efficiency, in-vitro drug release, differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and for stability studies. Among all formulations NLC7 was found to be an optimized formulation on the basis of small particle size 54.50 nm, higher entrapment efficiency 93.04±0.22%, and higher in-vitro cumulative drug release 86.48%. DSC studies reveal that aspirin was stable in final formulation and compatibility with selected excipients in the formulation. Formulated NLCs loaded ASP nanoparticles can be deliver through oral, parenteral or topical routes for improvement of bioavailability and to avoid GI side effects of ASP.
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